Differential Bio is a biotechnology company based in Munich that specializes in optimizing and scaling biomanufacturing processes through its AI-powered Virtual Scale-up Platform. Combining lab automation, microbiological innovation, and machine learning, the platform accelerates bioprocess development and reduces the costs and timelines associated with traditional scale-up. It is designed for biotech companies producing bio-based materials, proteins, or compounds that require precision fermentation and rapid commercialization.

What are the main features of Differential Bio?

Miniaturized fermentation technology

The platform enables small-scale, high-throughput fermentation experiments, allowing rapid testing of microbial strains and process parameters. This provides:

• Faster identification of optimal growth conditions

• Efficient use of materials and resources

• Early-stage insights into production performance

Automated laboratory workflows

Using robotic systems and integrated software, Differential Bio automates routine lab tasks, which leads to:

• High-volume data collection with consistent quality

• Reproducible experiments across batches

• Minimal manual labor and reduced error rates

AI-driven simulation and optimization

The core of the platform uses machine learning models to simulate and predict the outcomes of bioprocesses. These capabilities support:

• Virtual experimentation before physical scale-up

• Rapid optimization of yield, titer, and productivity

• Reduction in costly pilot and production-scale testing

End-to-end bioprocess support

Differential Bio covers all critical stages of bioprocess development, including:

• Microbial strain selection and medium formulation

• In-silico scale-up predictions and process adjustments

• Downstream processing and product stability evaluation

This integrated approach ensures each element of the production pipeline is optimized.

Why choose Differential Bio?

• Faster time-to-market by significantly reducing the bioprocess development cycle

• Lower development costs through predictive modeling and fewer physical experiments

• More sustainable production by optimizing resource use and reducing waste

• Increased yield and efficiency via machine learning-driven process tuning

• Comprehensive solution spanning lab-scale testing to industrial scale-up

Differential Bio enables bio-based product manufacturers to bring innovations to market faster and more efficiently, with technology tailored to the complexities of modern biomanufacturing.